|
KMID : 0191120220370350267
|
|
Journal of Korean Medical Science
2022 Volume.37 No. 35 p.267 ~ p.267
|
|
|
Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination
|
|
Kim Sung-Ran
Kang hyeon-Jeong
Jeong Hye-Rin
Jang Su-Yeon
Lee Jae-Eun
Kim Da-Eun
Lee Hae-Ry
Cho Min-Hee
Noh Ji-Yun
Cheong Hee-Jin
Kim Woo-Joo
Song Joon-Young
|
|
|
Abstract
|
|
|
|
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
|
|
|
KEYWORD
|
|
|
SARS-CoV-2, COVID-19, Healthcare Worker, Vaccine Effectiveness
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|